In this paper, in order to carry forward the new urbanization and ensure the implementation of the urban work under the background of the supply-side structural reform, the contradiction between supply and demand in the city is conducted from the supply and demand sides, and the general objective of building the people-oriented high quality city in the urban supply-side structural reform is put forward, and the emphasis shall be given to the effective supply of the factors such as urban land, labor force, capital, technology, etc.; in addition, some thoughts and suggestions are proposed on how to promote the structural reform of the urban supply side in Guangdong Province from the perspective of planning, construction, management and the integration of planning, construction and management. By strengthening the urban planning and construction management, as a key link and effective grasp of the urban supply side structural reform, the transformation and innovation of urban and rural development and construction model can be promoted.